We do not provide the User's Guide portion of the Help as a PDF file, as the cross references and links provided in the help are very useful, and it wouldn't be very useful to read it from top to bottom.

Here are links to most portions of the Prism 5 help as PDF files: There is no need to first select a range of data to analyze. This is installed automatically with Prism (including the free demo). Start from any data table or graph, and click the Analyze button. All the information about Prism (including statistics and regression) is contained in one unified and searchable help system. Within 45 min I had generated eight graphs without reading one word of the documentation Obviously I began my formal review. Prism no longer comes with printed manuals. You can also use the Send-to-PowerPoint or Send-to-Word buttons. Alternatively, drop the File menu and choose Export. Click the Export button on the Prism toolbar to bring up the Export Graph dialog. All three guides are also available as PDF files: Start from one graph or a layout, or from several graphs or layouts selected on the Gallery. The help is online (web-based) so we can update it frequently.

All three guides are also available as PDF files:

Graphpad prism 8 user guide